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本文采用 APAAP 法测定哮喘患儿外周血淋巴细胞中 IL-4、IFN-r 分泌细胞阳性率。哮喘发作组 IL-4分泌细胞阳性率显著高于缓解组和正常对照组,P<0.001。缓解组与正常对照组相比也有显著性差异,P<0.01。IFN-r 分泌细胞阳性率各组间无显著性差异,P>0.05。哮喘患儿 IL-4分泌细胞阳性率与血清总 IgE 有显著相关性,r=0.58,P<0.01。提示,哮喘患儿 IL-4分泌过多,IFN-r 分泌相对不足,这可能是 IgE 过多合成的原因之一。
In this paper, the APAAP method was used to determine the positive rate of IL-4 and IFN-γ secreting cells in peripheral blood lymphocytes of asthmatic children. The positive rate of IL-4 secreting cells in asthma attack group was significantly higher than that in remission group and normal control group (P <0.001). There was also a significant difference between the remission group and the normal control group (P <0.01). The positive rate of IFN-γ secreting cells in each group had no significant difference, P> 0.05. The positive rate of IL-4 secreting cells in children with asthma was significantly correlated with the total serum IgE, r = 0.58, P <0.01. Tip, asthmatic children with excessive IL-4 secretion, IFN-r secretion is relatively inadequate, which may be one of the reasons for excessive IgE synthesis.