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目的探讨化疗在晚期复治肿瘤患者治疗中的作用及不同化疗方式的应用意义。方法以回顾性研究方式收集整理了259例患者的临床资料,按接受不同治疗分为介入化疗组(A组)、减量热化疗组(B组)、常规静脉化疗组(C组),比较在不同肿瘤之间各组的临床总有效率、中位生存期(MST)及总生存率。结果A、B、C组肿瘤有效率分别为31.2%、20.0%和6.2%(A、B组与C组相比,P<0.01),中位生存期分别为6.20、9.87和6.78个月。3组近期生存率差异无显著性,但23年生存率以热化疗(B组)为高,分别为33.3%及12.5%。结论单纯静脉化疗肿瘤缓解率较低,介入化疗有效率较高,但并不一定延长生存率;减量热化疗在提高复治患者的有效率,延长生存期方面有积极意义。
Objective To investigate the role of chemotherapy in the treatment of patients with advanced retreatment of cancer and the application significance of different chemotherapy methods. METHODS: The clinical data of 259 patients were collected and retrospectively reviewed and divided into intervention chemotherapy group (A group), reduced-calorie chemotherapy group (B group), and conventional intravenous chemotherapy group (C group) according to different treatment. Clinical total effective rate, median survival time (MST) and overall survival rate among different groups of tumors. Results The effective rates of tumors in group A, B and C were 31.2%, 20.0% and 6.2% (P<0.01 for group A and B compared with group C). The median survival time was 6.20, 9.87 and 6.78 months, respectively. There was no significant difference in the recent survival rates among the three groups, but the 23-year survival rate was higher with thermochemotherapy (group B), which was 33.3% and 12.5%, respectively. Conclusions The rate of tumor remission is relatively low for intravenous chemotherapy alone, and the efficiency of interventional chemotherapy is higher, but it does not necessarily prolong the survival rate. Reduced calorie chemotherapy has positive significance in improving the efficiency of retreatment patients and prolonging survival.