Leser-Trélat征并发恶性黑棘皮病的情况并不多见。李顺凡等[1]1991年曾报告1例,国外文献报道较多[2-4]。4年前笔者曾诊治1例该病患者,对皮损给予常规治疗,效果不佳。随访4年后患者死于食管癌。现报告如下。1病历摘要患者男,65岁。因双下肢起淡白色、肤色丘疹3个月,泛发全身伴 Leser-Trélat signs of malignant Acanthosis nigricans are rare. Li Shun et al [1] 1 case was reported in 1991, more foreign literature [2-4]. 4 years ago, I had diagnosis and treatment of a patient with the disease, conventional treatment of lesions, the effect is not good. Four years after the patient died of esophageal cancer. The report is as follows. Patient male, 65 years old. Due to the lower extremities pale, skin color pimple 3 months, generalized with the whole body