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近年研究表明石棉是一种遗传毒性致癌物,其诱变作用以大片段、多位点基因缺失为特征。诱变机制包括对分裂期细胞染色体的直接干扰作用和通过活性氧类的间接作用。石棉致癌与癌基因或抑癌基因突变的关系,因缺乏足够而一致的报道故未作确切结论;石棉可诱导靶细胞内某些与细胞增殖有关的原癌基因表达增强,而加速的细胞增殖可促进诱变过程。
Recent studies have shown that asbestos is a genotoxic carcinogen and its mutagenesis is characterized by the deletion of large fragments and multiple loci. Mutagenesis mechanisms include direct interference with chromosomes in dividing cells and indirect effects through reactive oxygen species. The association between asbestos carcinogenesis and oncogene or tumor suppressor gene mutations has not been conclusive due to lack of adequate and consistent reports; asbestos can induce enhanced expression of proto-oncogenes associated with cell proliferation and accelerated cell proliferation in target cells. Can promote the mutagenesis process.