一氧化氮(NO)作为一种新发现的信使分子,是近年研究的热点之一。细菌成分和(或)细胞因子可诱导某些细胞生成NO合成酶(NOS)合成NO,参与机体多种反应过程。可编码这种诱生型NOS(iNOS)的cDNA已从数种细胞在克隆成功。通过对cDNA编码蛋白同源性、功能区组成及表达的研究,使得对iNOS的认识更加深入。 Nitric oxide (NO), as a newly discovered messenger molecule, is one of the hot spots in recent years. Bacterial components and / or cytokines can induce some cells to produce NO synthase (NO) to synthesize NO, which is involved in various reaction processes in the body. CDNA encoding this inducible NOS (iNOS) has been cloned from several cells. Through the study of the protein homology, functional domain composition and expression of cDNA, the cognition of iNOS is further deepened.