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病原菌首先与宿主接触的部位是粘膜表面。在粘膜表面抗菌过程中,分泌型IgA(SIgA)起重要作用。然而sIgA发挥抗菌活性的机制仍是个争议的问题。自从在人类、兔、豚鼠和鼠的淋巴细胞、单核细胞和粒细胞表面发现IgA的Fc段受体,提出了IgA也介导依赖抗体细胞的细胞毒性(ADCC)。其实被人类白细胞介导的ADCC是在有循环型IgA情况下证明的。当发现这些细胞的表面受体也能结合slgA时,作者决定研究当sIgA结合到淋巴细胞上时,是否也能介导ADCC起抗菌作用。
Pathogens first contact with the host site is the mucosal surface. Secretory IgA (SIgA) plays an important role in the antimicrobial process on the mucosal surface. However, the mechanism by which sIgA exerts antibacterial activity remains a matter of debate. Since the discovery of IgA Fc receptor on the surface of human, rabbit, guinea pig and mouse lymphocytes, monocytes and granulocytes, IgA has been proposed to also mediate antibody dependent cell cytotoxicity (ADCC). In fact, human leukocyte-mediated ADCC is demonstrated in the presence of circulating IgA. When it was discovered that the surface receptors of these cells could also bind slgA, the authors decided to investigate whether sIgA could also mediate the antimicrobial activity of ADCC when bound to lymphocytes.