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目的探讨氧驱动雾化吸入布地奈德混悬液治疗小儿哮喘急性发作的疗效及其对肺功能的影响。方法选取达州市妇幼保健院2015年1月—2016年1月收治的小儿哮喘急性发作患儿68例,采用掷硬币法随机分为对照组和观察组,各34例。对照组采用常规治疗,观察组采用氧驱动雾化吸入布地奈德混悬液治疗,1个疗程后对比两组患儿各临床症状缓解或消失时间、用力肺活量(FVC)、第1秒用力呼气末容积(FEV1)、最大呼气流量(PEF)、FEV1/FVC及药物不良反应发生情况。结果观察组患儿咳嗽、喘憋缓解时间及肺部哮鸣音消失时间均短于对照组,差异有统计学意义(P<0.05)。观察组FVC、FEV1及FEV1/FVC均高于对照组,差异有统计学意义(P<0.05);两组PEF比较,差异无统计学意义(P>0.05)。观察组不良反应发生率为14.7%(5/34),低于对照组的50.0%(17/34),差异有统计学意义(P<0.05)。结论氧驱动雾化吸入布地奈德混悬液治疗小儿哮喘急性发作较一般药物治疗疗效显著,可有效缓解患儿症状、恢复肺通气功能,且不良反应少,具有一定的临床应用价值。
Objective To investigate the curative effect of oxygen-driven inhalation of budesonide suspension on acute asthma attack in children and its effect on pulmonary function. Methods Sixty-eight children with acute asthma in pediatric asthma admitted to Dazhou Maternal and Child Health Hospital from January 2015 to January 2016 were randomly divided into control group and observation group by coin tossing method, 34 cases in each group. The control group was treated with conventional therapy. The observation group was treated with aerosol inhalation of budesonide suspension. After one course of treatment, the clinical symptoms relief or disappearance time, forced vital capacity (FVC) Inflatable volume (FEV1), the maximum expiratory flow (PEF), FEV1 / FVC and adverse drug reactions occurred. Results The cough, asthmatic relief time and disappearance time of lung wheeze in the observation group were all shorter than those in the control group (P <0.05). The FVC, FEV1 and FEV1 / FVC in the observation group were significantly higher than those in the control group (P <0.05). There was no significant difference in PEF between the two groups (P> 0.05). The incidence of adverse reactions in the observation group was 14.7% (5/34), which was lower than that in the control group (50.0%, 17/34). The difference was statistically significant (P <0.05). Conclusions Oxygen-driven inhalation of budesonide suspension in children with acute asthma attack is more effective than the general drug therapy, which can effectively relieve the symptoms of children and restore pulmonary ventilation with less adverse reactions, which has a certain clinical value.