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为观察马桑内酯诱导鼠癫痫持续状态（SE）时海马细胞中DNA损伤及凋亡现象，用流式细胞术检测雄性SD大鼠海马细胞中DNA状态，用免疫组织化学法显示海马谷氨酸阳性细胞，并用流式细胞术免疫荧光法测定海马细胞中BCI－2样蛋白含量。结果发现，致痫大鼠SE后海马神经细胞存在DNA断裂
In order to observe DNA damage and apoptosis in hippocampal cells induced by epilepsy, the DNA status of hippocampus of male SD rats was detected by flow cytometry. Immunohistochemistry was used to detect the changes of hippocampal glutamate Acid-positive cells, and using flow cytometry immunofluorescence assay of BCI-2-like protein content in hippocampal cells. The results showed that there is DNA breakage in the hippocampal neurons of SE rats