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较高浓度的氧氟沙星注射液(2ml:200mg)在制备及贮藏过程中易氧化,使溶液颜色加深,影响质量。我们经过实验,以亚硫酸氢钠(0.1%)与半胱氨酸(0.1%)作联合抗氧剂,同时,配料时煮沸15分钟,灭菌采取100℃30分钟或105℃20分钟的方法,所得样品各质量指标稳定。
Higher concentrations of ofloxacin injection (2ml: 200mg) in the preparation and storage process of easy oxidation, the color of the solution deepened, affecting the quality. We experimented with sodium bisulfite (0.1%) and cysteine (0.1%) as a combined anti-oxidant, while cooking ingredients for 15 minutes, sterilization to take 100 ℃ 30 minutes or 105 ℃ 20 minutes method, the resulting sample quality indicators of stability.