论文部分内容阅读
目的了解血吸虫病流行区HBsAg人群分布规律及其与血吸虫感染的相关性。方法在安徽省一中度血吸虫病流行村,采用病原学方法(Kato-Katz法,二送六检)和血清学方法(ELISA法、I HA法串联筛检方案)进行血吸虫感染情况检测,同时平行检测HBsAg(ELISA法),并进行相关个案调查。结果1)居民HBsAg阳性率11.21%(105/937),其中男性12.38%(50/404),女性10.32%(55/533),性别间差异无显著性(wald=1.545,P=0.214);25~34岁及以上年龄组HBV感染的危险度(OR)是5~14岁组的8.852~10.511倍(P均<0.001);2)血吸虫抗体阳性率与HBsAg携带率年龄性别分布曲线走向基本一致,有随年龄增大而上升趋势;≥25岁居民血吸虫抗体阳性率、粪检阳性率、HBsAg携带率分别在30%、3.13%和10%以上;3)慢性血吸虫病患者与非血吸虫病患者HBsAg携带率分别为7.69%和9.96%,HBsAg平均A值分别为0.180(-0.005,0.364)和0.234(0.141,0.327),差异无显著性(P均>0.05)。血吸虫抗体阳性与阴性者HBsAg携带率分别为12.26%、10.66%,HBsAg平均A值分别为0.246(0.166,0.327)和0.241(0.182,0.301),差异无显著性(P均>0.05)。结论本研究未发现HBV与血吸虫感染有相关性,但≥25岁居民血吸虫合并HBV感染的潜在威胁不能忽视。
Objective To understand the distribution of HBsAg in schistosomiasis endemic areas and its relationship with schistosomiasis infection. Methods The schistosomiasis infection was detected in a moderate schistosomiasis endemic village in Anhui Province by pathogenic methods (Kato-Katz method, two-for-six tests) and serological methods (ELISA, IHA method) Parallel detection of HBsAg (ELISA method), and the relevant case investigation. Results The positive rate of HBsAg in residents was 11.21% (105/937), including 12.38% (50/404) males and 10.32% females (55/533). There was no significant difference between the sexes (wald = 1.545, P = 0.214). The risk of HBV infection was 8.852-10.511 in the age group of 5 ~ 14 years old (P <0.001). 2) The age distribution curve of schistosoma antibody positive rate and HBsAg carrier rate The positive rate of HBsAg and HBsAg carrier rate were above 30%, 3.13% and 10%, respectively; 3) In patients with chronic schistosomiasis and non-schistosomiasis The carrier rate of HBsAg was 7.69% and 9.96% respectively, and the average A value of HBsAg was 0.180 (-0.005,0.364) and 0.234 (0.141,0.327) respectively, with no significant difference (all P> 0.05). The HBsAg carrier rates of schistosoma japonicum antibody positive and negative were 12.26% and 10.66% respectively, and the average A value of HBsAg was 0.246 (0.166,0.327) and 0.241 (0.182,0.301) respectively, with no significant difference (all P> 0.05). Conclusion The study found no correlation between HBV and schistosomiasis, but the potential threat of schistosomiasis with HBV infection in ≥25 years of age can not be ignored.