论文部分内容阅读
以廉价易得的苯酚和马来酸酐为原料,经直接酰基化、I2催化下分子内关环、环丙烷化、酯化、然后成肟得(1a RS,7a RS)-7-羟基氨亚基-1,1a,7,7a-4H-丙环骈[b]色烯-1a-甲酸乙酯及其衍生物的有效全合成及其系列的衍生物.本研究改进了色酮骨架的构建方法,并采用约翰逊–科里–柴可夫斯基反应进行色酮骨架上的环丙烷化反应.所有中间体以及目标产物的结构均由1H NMR,13C NMR和ESI-MS确证.该路线5步反应的总收率为20.1%~29.5%.
A cheap and readily available phenol and maleic anhydride as raw materials, by direct acylation, I2 catalytic intramolecular ring closure, cyclopropanation, esterification, and then into the oxime (1a RS, 7a RS) -7- hydroxy ammonia Efficient Synthesis of Ethyl-1, 1a, 7,7a-4H-Propacycloocta [b] chromene-1α-carboxylate and its Derivatives and Their Derivatives This study improved the construction of the chromone backbone Method and cyclopropanation on the chromone backbone using the Johnson-Coriolis-Tchaikovsky reaction The structures of all intermediates and the target product were confirmed by 1H NMR, 13C NMR and ESI-MS The route 5 The total yield of the step reaction is 20.1% ~ 29.5%.