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合成和表征了一种新的N-苯基二吡啶甲基胺(phdpa)铜配合物[(phdpa)Cu(SCN)](ClO4)。X-衍射晶体结构数据显示配合物中铜原子与配体phdpa中3个N原子、SCN-中S原子和邻近分子中SCN-中N原子配位,形成扭曲八面体结构。生物活性数据显示该铜配合物抑制HepG-2细胞的生长,半数抑制率为10.4μmol.L-1。进一步机理研究数据显示这种SCN-桥联的铜配合物能诱导HepG-2细胞核的分裂,降低其耗氧量和ROS的含量,这表明该铜配合物是一种能影响HepG-2细胞氧代谢的多功能配合物。
A new copper complex of phdpa [(phdpa) Cu (SCN)] (ClO4) was synthesized and characterized. X-diffraction crystal structure data show that the copper atom in the complex is coordinated with the three N atoms in the phdpa ligand and the SCN-intermediate S atom in the SCN- and the N atom in the adjacent molecule to form a twisted octahedron structure. The biological activity data showed that the copper complex inhibited the growth of HepG-2 cells with a half-value inhibition rate of 10.4 μmol·L-1. Further mechanistic studies suggest that this SCN-bridged copper complex induces the cleavage of the HepG-2 cell nucleus and reduces its oxygen consumption and ROS content, suggesting that the copper complex is a cytosolic oxygen species capable of affecting HepG-2 cell oxygen Metabolic multifunctional complexes.