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目的:分析施行《抗菌药物临床应用管理办法》限制抗菌药物品种、品规政策对医院抗菌药物消耗量的影响。方法:回顾性统计我院经抗菌药物目录调整期间(2011~2014年),抗菌药物的品种数量、品规数量、销售金额、用药频度随时间阶段的变化情况。结果:抗菌药物管理政策落实后,抗菌药物品种数从2011年的97种降至2012年的49种,品规数从2011年的255个降至2012年的84个。2011年销售前10品种中的特殊使用级、限制级药品在2012年的前10品种中使用份额显著下降,2011年使用频度最高的三代头孢菌素头孢地嗪(DDDs值=11 2625)随后被一代头孢(头孢唑啉或头孢硫脒)所取代;2011年排名前10品规占抗菌药物销售金额比例最低25.74%,随后3年逐年递增,依次为54.63%、60.87%、56.97%。结论:《抗菌药物临床应用管理办法》实施以来,我院抗菌药物使用结构、数量及金额发生显著改变,有助于药品规范化管理及临床合理应用。
OBJECTIVE: To analyze the impact of the implementation of the “Administrative Measures on the Clinical Application of Antibacterials” to limit the variety of antibacterial drugs and the rules and regulations on the antimicrobial consumption of the hospital. Methods: The retrospective statistics of our hospital during the adjustment of antimicrobial inventory (2011 ~ 2014), the number of varieties of antimicrobial drugs, the number of products, the amount of sales, medication frequency changes over time. Results: After the implementation of the antimicrobial management policy, the number of antimicrobial drugs dropped from 97 in 2011 to 49 in 2012, with the number of products and regulations dropping from 255 in 2011 to 84 in 2012. The share of restricted use drugs in the top 10 varieties in 2012 was significantly lower for the first 10 categories of sales in 2011 and the third generation cephalosporin cefodizime used the most frequently in 2011 (DDDs = 11 2625) Was replaced by cephalosporin (cefazolin or cefathiamidine). The top 10 products accounted for the lowest 25.74% of the total sales of antibacterial drugs in 2011, and then increased year by year in the following three years, followed by 54.63%, 60.87% and 56.97% respectively. Conclusion: Since the implementation of the Administrative Measures for the Clinical Application of Antibacterials, the structure, quantity and amount of antibacterials used in our hospital have changed significantly, which is helpful for the standardized management of medicines and their clinical application.