本文就肝素对实验性ARF的作用进行了观察、比较,在客观上提示肝素有减轻肾小管上皮损害、维持肾小球滤过和防止管型形成的作用。结合对ARF发生机理的回顾,认为ARF早期系肾脏血流动力学改变所致的功能性损害,肾小球毛细血管内凝血是肾脏从功能性损害发展到实质性损害的症结所在。本实验为肝素的临床应用提供了初步依据。 In this paper, the effect of heparin on experimental ARF were observed and compared objectively suggesting that heparin can reduce renal tubular epithelial damage, maintain glomerular filtration and prevent tube formation. Combined with the review of the mechanism of ARF, ARF early Department of renal hemodynamic changes caused by functional impairment, glomerular capillary coagulation is the development of renal damage from the functional damage to the crux of the substantive damage. This experiment provides a preliminary basis for the clinical application of heparin.