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目的 比较不同心功能级数慢性心力衰竭 (CHF)患儿治疗前后血清Ⅲ型前胶原 (PCⅢ )、透明质酸 (HA)和层粘蛋白 (LN)含量的变化 ,观察心肌纤维化指标对该病的影响。方法 用放射免疫法对 80例慢性心力衰竭 (CHF)患儿血清PCⅢ、HA和LN含量进行测定。结果 80例CHF患儿血清PCⅢ、HA和LN含量分别为 180 33± 32 5 6 μg/L、88 2 5± 2 9 14 μg/L和 132 4 5± 2 6 33μg/L ,与正常对照组比较差异有显著意义 (P均 <0 0 1) ;心功能Ⅱ级和Ⅲ级病人上述 3项指标明显高于心功能Ⅰ级 (P <0 0 5 )者 ,且升高程度与心功能级数相平行 ;不同心功能级数CHF患儿血清PCⅢ、HA和LN纤维 3项含量治疗后较治疗前明显降低 (P <0 0 5～ 0 0 1)。结论 CHF患儿血清PCⅢ、HA和LN含量升高 ,可能与心功能状况有关 ,抗纤维化治疗对CHF病人有一定的疗效。
Objective To compare the changes of serum levels of type Ⅲ procollagen (PC Ⅲ), hyaluronic acid (HA) and laminin (LN) before and after treatment in children with different grades of chronic heart failure (CHF) The impact of disease. Methods Serum PCⅢ, HA and LN in 80 children with chronic heart failure (CHF) were determined by radioimmunoassay. Results The serum levels of PCⅢ, HA and LN in 80 CHF patients were 180 33 ± 32 56 μg / L, 88 2 5 ± 29 9 μg / L and 132 45 ± 2 6 33 μg / L, respectively. Compared with the normal control group (P <0.01). The above three indexes in patients with gradeⅡand Ⅲ of cardiac function were significantly higher than those with gradeⅠ (P0.05), and the degree of increase was positively correlated with the level of cardiac function The levels of PCⅢ, HA and LN in serum of CHF patients with different cardiac function scores were significantly lower than those before treatment (P <0.05-0.01). Conclusion Serum levels of PCⅢ, HA and LN in children with CHF may be related to cardiac function. Antifibrosis treatment may have some effects on CHF patients.