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目的探讨癫痫患儿采用丙戊酸钠治疗对甲状腺功能的影响。方法 45例行丙戊酸钠治疗的癫痫患儿治疗前、治疗后3个月及治疗后6个月的甲状腺功能进行对比,同时选取45例门诊检查正常儿童作为对照组,对其甲状腺功能进行检测,并和观察组进行比较。结果治疗前两组患儿总甲状腺素(T4)、总三碘甲状腺原氨酸(T3)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)水平比较差异均无统计学意义(P>0.05),观察组患儿治疗前及治疗后3、6个月甲状腺激素水平比较差异均无统计学意义(P>0.05)。结论给予癫痫患儿丙戊酸钠治疗不会对其甲状腺功能造成影响。
Objective To investigate the effect of sodium valproate on thyroid function in children with epilepsy. Methods 45 cases of epilepsy patients treated with sodium valproate before treatment, 3 months after treatment and 6 months after treatment of thyroid function were compared at the same time select 45 cases outpatient examination of normal children as control group, its thyroid function Test, and compared with the observation group. Results The levels of total thyroxine (T4), total triiodothyronine (T3), free triiodothyronine (FT3), free thyroxine (FT4) and thyrotropin (TSH) There was no significant difference between the two groups (P> 0.05). There was no significant difference in the level of thyroid hormone between the observation group and before treatment (P> 0.05). Conclusion The treatment of sodium valproate in children with epilepsy will not affect the thyroid function.