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作者等设计了预计有高度活性的一系列多功能基化合物,其中,2,4-二氨基-6-(双-2-氯乙基)氨甲基蝶啶呈现很高的抗癌活性。其结构包含MTX 的蝶啶基部分,并以共价键连接烷化剂的烷化部分:
The authors designed a series of multifunctional compounds expected to be highly active, of which 2,4-diamino-6- (bis-2-chloroethyl) aminomethyl pteridine exhibited high anticancer activity. Its structure contains the pteridinyl moiety of MTX and covalently bonds the alkylating moiety of the alkylating agent: