今报告我院采用甲硝唑治疗消化性溃疡病249例,取得较好的效果,现总结如下。 一、临床资料 全部病例均经纤维胃镜确诊为活动性消化性溃疡,其中十二指肠球部溃疡135例,(占54.2％),胃溃疡78例,(占31.32％),幽门管溃疡9例,(占3.61％),复合性溃疡24例,(占9.63％),球后溃疡3例,(占1.2％)。男性217例,女性32例,男女之比为6.78∶1,年龄最小16岁,最大78岁,平均年龄42.05岁。均先作肝功能、血、尿、粪常规检查,服药期间每周记录症状、体征和不良反应,疗程结束由原同一内镜医师作胃镜复查,观察疗效。 1.分组 按就诊次序随机分成甲硝唑组,甲氰咪胍组和安慰剂组,每组83例,三组年龄、溃疡类型、病程及合并症均相近(P>0.05)。所用药物的剂型、颜色、用法相似。以双盲法观察疗效。 This report uses metronidazole in our hospital 249 cases of peptic ulcer disease, and achieved good results, are summarized as follows. First, clinical data All cases were diagnosed as active peptic ulcer by fiber endoscopy, of which 135 cases of duodenal ulcer (54.2%), gastric ulcer in 78 cases (31.32%), pyloric tube ulcer 9 Cases (3.61%), composite ulcer in 24 cases (9.63%), ball ulcer in 3 cases (1.2%). There were 217 males and 32 females, with a ratio of 6.78:1. The youngest was 16 years old and the youngest was 78 years old, with an average age of 42.05 years. All were routinely checked for liver function, blood, urine and feces, and weekly symptoms, signs and adverse reactions were recorded during the medication. The treatment was completed by the same endoscopist for endoscopy and the curative effect was observed. The patients were randomly divided into metronidazole group, cimetidine group and placebo group, with 83 cases in each group. The three groups were similar in age, ulcer type, course of disease and comorbidity (P> 0.05). Drug dosage forms, colors, usage similar. Double-blind observation of efficacy.