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目的 :探讨肝硬化患者红细胞膜脆性和血流变指标的改变。方法 :采集肝硬化病人抗凝血标本 ,用 NBY- 6全自动血流变仪测定红细胞变形指数、刚性指数、聚集指数、电泳时间等血流变相关指标 ,根据全国临检操作规程推荐的方法作红细胞孵育脆性试验 ,并将结果与正常人对比。结果 :56例肝硬化病人和 2 6例健康人的红细胞变形指数、刚性指数、聚集指数、电泳时间等指标与对照组相比均有显著性差异 ,红细胞孵育前后的渗透脆性明显增加。结论 :肝硬化病人的红细胞膜结构和血流变指标均有明显异常的改变 ,其原因可能与肝脏的物质合成障碍以及红细胞膜被某些特异性物质修饰有关
Objective: To investigate the changes of erythrocyte membrane fragility and hemorheology in cirrhotic patients. Methods: The anticoagulant samples of patients with cirrhosis were collected. The relative index of erythrocyte deformation index, rigidity index, aggregation index and electrophoresis time were determined by NBY-6 automatic blood rheometer. According to the recommended method Erythrocyte incubation fragility test, and the results compared with normal. Results: The indexes of erythrocyte deformability index, rigidity index, aggregation index and electrophoresis time in 56 patients with cirrhosis and 26 normal controls were significantly different from those in control group. The osmotic fragility of erythrocytes increased obviously before and after incubation. CONCLUSIONS: The changes of erythrocyte membrane structure and hemorrheological indexes in patients with cirrhosis are obviously abnormal. The reason may be related to the obstruction of substance synthesis in liver and the modification of erythrocyte membrane by some specific substances