[例1]男,49岁,工人。因间歇性小关节肿痛25年,尿频、尿急反复发作4年入院。以两手指及足趾关节为主,多次求医均诊断为“风湿性关节炎”,服用激素有效。近4年出现上述关节畸形,且有尿频、尿急、腰痛、血尿。当地医院诊断为“尿路感染”,但庆大霉素等抗菌治疗无效。查体:全身无浮肿,两手第一掌指关节及两足第一跖趾关节畸形,可触及2个隆起结节,无触痛,腹部平片未见阳性结石.化验:蛋白(+),白细胞(++),红细胞(++),草酸钙结晶(+++);血尿酸0.18g/L,尿尿酸1.3g/d,血沉 [Example 1] Male, 49 years old, worker. Due to intermittent small joint swelling and pain for 25 years, frequent urination, urinary urgency recurrent 4 years admitted. With two fingers and toe joints, multiple medical consultations were diagnosed as “rheumatoid arthritis”, taking hormone effective. The past 4 years the above-mentioned joint deformity, and frequent urination, urgency, back pain, hematuria. The local hospital diagnosed as “urinary tract infection,” but antibacterial treatment gentamicin invalid. Physical examination: the whole body without edema, both hands the first metacarpophalangeal joint and two feet first metatarsophalangeal joint deformity, palpable two uplift nodules, no tenderness, abdominal plain film no positive.Study: protein (+), White blood cells (++), red blood cells (++), calcium oxalate crystals (+++); uric acid 0.18g / L, uric acid 1.3g / d, ESR