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1979年,Anderson NG及Anderson NL粗略估计,人体基因组大约可以合成30000～50000种蛋白质。这些基因并不全部表达出来,一种细胞通常能合成的蛋白质只不过是这个数目的百分之几。现已查明,有几种可溶性胞浆蛋白质主要存在于神经组织。这些蛋白质不仅是神经细胞的特异性蛋白质,而且它们在神经组织里的分布也有其特异性。如γγ-烯醇化酶(EC 4.2.1.11)只出现于某些神经原,而神经胶质原纤维酸性蛋白质则只存在于特定的神经胶质细胞。这种组织特异性加上细胞特异性,为临床生化学提供了检查神经系统损伤的新方法的理论基
In 1979, Anderson NG and Anderson NL roughly estimated that the human genome could synthesize about 30,000-50,000 proteins. These genes are not all expressed, a cell usually can synthesize a protein is only a few percent of this number. It has been identified, there are several soluble cytoplasmic protein mainly in nerve tissue. These proteins are not only specific neuronal proteins, but also their distribution in nerve tissue is also specific. Gamma-enolase (EC 4.2.1.11) appears only in certain neurons, whereas glial fibrillary acidic protein is found only in specific glial cells. This tissue specificity, coupled with cell specificity, provides the rationale for clinical biochemistry to find new ways to check for nervous system damage