目的:促进临床大环内酯类药的合理应用。方法:收集某医院2009年8～9月门诊含克拉霉素、环脂红霉素口服片剂处方共579张,对其进行综合评价。结果:环脂红霉素片、克拉霉素缓释片、克拉霉素分散片不合理用药率分别为22.1%,34.2%,31.8%。具体表现在:非适应证用药、单一用药不合适、疗程过短、剂量不足、联合用药存在相互作用等。结论:应对大环内酯类药在临床中的不合理应用进行审核干预,保证患者用药安全、合理。 Objective: To promote the rational use of macrolides in clinical medicine. Methods: A total of 579 oral tablets containing clarithromycin and cyclopsin were collected in a hospital from August to September in 2009 and were evaluated comprehensively. Results: The irrational drug use rates of clarithromycin tablets, clarithromycin tablets and clarithromycin tablets were 22.1%, 34.2% and 31.8% respectively. Specific manifestation of: non-indications medication, a single medication inappropriate, short course of treatment, lack of dose, there is interaction between the combination of drugs. Conclusion: The macrolides in the clinical application should be unreasonable audit intervention to ensure that patients medication safe and reasonable.