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1972年Liebow等首先记载了淋巴瘤样肉芽肿(Lymphomatoid granulomatosis,简称LYG),其临床及组织学表现类似Wegener肉芽肿(简称WG)与不典型淋巴瘤。组织学特征为有大量淋巴细胞、浆细胞、组织细胞及不典型淋巴—网状细胞,呈血管中心性(angioc-enfric)及血管破坏性(angiodestrucfive)浸润的坏死性肉芽肿(1～14)。病变主要累及肺,其次是皮肤、神经系统及肾间质(1～3,5～7,12)。最初发现有些LYG可转化为免疫母细胞肉瘤或不典型淋巴瘤,认为本病可能与淋巴瘤有
In 1972, Liebow et al first described Lymphomatoid granulomatosis (LYG), which showed similar clinical and histological features as Wegener’s granulomatosis (WG) and atypical lymphoma. Histological features are necrotic granulomas (1-14) that are infiltrated with angioc-enfric and angiodestrucfive cells with a large number of lymphocytes, plasma cells, tissue cells and atypical lymphatic-reticular cells . Lesions mainly involve the lungs, followed by the skin, the nervous system, and the renal interstitium (1 ~ 3,5 ~ 7,12). Initially found that some LYG can be transformed into immunoblastic sarcoma or atypical lymphoma, that the disease may be associated with lymphoma