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人参皂甙单体Rh_1和Rh_2给予接种S180肉瘤细胞3天后的载瘤小鼠腹腔注射,50mg/kg.d,连续7天。应用FACS 420荧光细胞激活器对肿瘤细胞进行周期分析发现,在短期内Rh_1对肿瘤细胞周期影响不大;Rh_2可阻断S_(180)肉瘤细胞从S期向G_2期过度(P<0.005),抑制肿瘤细胞生长。
Ginseng saponin monomers Rh_1 and Rh_2 were intraperitoneally administered to S180 sarcoma cells three days after inoculation, with a dose of 50 mg/kg.d for 7 consecutive days. Periodic analysis of tumor cells using the FACS 420 fluorescence cell activator revealed that Rh_1 had little effect on the tumor cell cycle in the short term; Rh 2 could block the S-180 sarcoma cell transition from S phase to G 2 phase (P<0.005). Inhibit tumor cell growth.