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在兔角膜表面置直径为９ｍｍ圆形４％可卡因滤纸片１０ｓ，９０ｓ，擦去松解上皮，保留角膜缘内２ｍｍ完整上皮区。手术后不同时间，用光镜及透射电镜观察４％可卡因对角膜的毒性作用。结果兔角膜上皮修复与滤纸片放置时间无关，角膜组织水肿恢复正常时间与滤纸片放置时间呈正相关。组织学上有明显差异，１０ｓ组角膜组织超微结构无明显改变；９０ｓ组角膜组织超微结构发生明显改变。提示４％可卡因溶液长时间应用对角膜尤其是内皮细胞层具有毒性作用。
In the corneal surface of rabbit diameter 9mm round 4% cocaine filter paper 10s, 90s, wipe off the release of epithelium, leaving 2mm intact epithelial zone within the limbus. At different times after operation, the toxic effects of 4% cocaine on the cornea were observed with light microscope and transmission electron microscope. Results The corneal epithelial repair in rabbit had no correlation with the time of filter paper placement, and the normal time of corneal edema was positively correlated with the filter paper placement time. There was obvious difference in histology. There was no significant change in the ultrastructure of corneal tissue in 10s group. The ultrastructure of corneal tissue in 90s group changed obviously. Tip 4% cocaine solution long-term application of corneal endothelial cells in particular, has a toxic effect.