为评价三苯氧胺对早期乳腺癌接受保守性手术和放射治疗而且其雌激素受体阳性患者的肿瘤复发、美容效果、并发症和生存率的影响,作者分析了1982～1991年间491例患者的资料。病人的年龄39～85岁,≤50岁者占21％。原发灶分期为T_1者占69％,T_2者占31％。所有肿瘤均经手术切除活检,其中49％行再次切除术,最后手术切缘有8％为阳性,18％不 To evaluate the effect of tamoxifen on conservative surgery and radiation therapy for early-stage breast cancer and its tumor recurrence, cosmetic outcomes, complications, and survival rates in estrogen receptor-positive patients, the authors analyzed data from 491 patients between 1982 and 1991. The patient’s age was 39 to 85 years old, and ≤ 50 years old accounted for 21%. 69% of primary tumors were T_1, and 31% were T_2. All tumors were surgically resected and biopsy was performed in 49% of them. The final surgical margin was 8% positive and 18% was not.