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目的:观察四子种王胶囊对生精细胞损伤模型大鼠睾丸组织一氧化氮合酶和抗氧化系统的影响。方法:以腺嘌呤灌胃SD大鼠,诱发生精细胞损伤大鼠模型。测定服用四子种王胶囊前后大鼠睾丸组织超氧化物歧化酶、一氧化氮合酶活性及一氧化氮、丙二醛含量。结果:四子种王胶囊可提高生精细胞损伤大鼠睾丸组织超氧化物歧化酶活性,降低一氧化氮合酶活性及一氧化氮、丙二醛含量。结论:四子种王胶囊对腺嘌呤诱发的大鼠生精细胞损伤具有保护作用。
Objective: To observe the effect of SiZi ZhongWang capsule on testis nitric oxide synthase and antioxidative system in spermatogenic cell injury model of rats. Methods: Adenine was injected intragastrically into SD rats to induce spermatogenic cell injury in rats. The contents of superoxide dismutase, nitric oxide synthase and contents of nitric oxide and malondialdehyde in testis of rats before and after taking SiZiWangWang capsules were measured. Results: Sizi Kaneo Capsule increased the activity of superoxide dismutase (SOD) and nitric oxide synthase (NO), malondialdehyde (MDA) and malondialdehyde (MDA) in testis of spermatogenic cells injured by spermatogenic cells in rats. Conclusion: Sizi Kaneo Capsule has a protective effect on adenine induced rat spermatogenic cell injury.