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应用激光多普勒血流仪测定大鼠后肢周围神经电刺激后腰髓血流的动态性变化。在保持刺激电压３．０Ｖ、频率５０Ｈｚ、脉冲时间１．０ｍｓ的实验条件下，腰髓血流迅速增加。电刺激１分钟时，腰髓局部血灌流量由原基线值２６４．６±１７．１ＰＵ增加到３１７．５±３５．４ＰＵ（Ｐ值＜０．００１）；持续刺激１５分钟，血灌流量增加到平均高峰值３６６．０±３５．７ＰＵ（Ｐ值＜０．００１）；血流速度由基线值７６．４±１６．１ＶＵ增至平均高峰值１１１．１±２３．４ＶＵ（Ｐ值＜０．００１）。停止电刺激后，腰髓血流逐渐减少并回复至基线水平。神经电刺激时间越长，腰髓血流返回至基线水平所需的时间就越长。腰髓血流的增加与动脉血压的变化无关。刺激主要含运动纤维的胫后神经，其腰髓血流的增加明显低于对混合性神经坐骨神经和腓神经的刺激结果。上述结果对于临床上经皮电刺激缓解疼痛提供了理论依据。
Dynamic change of lumbar cord blood flow after peripheral nerve stimulation of hindlimb using laser Doppler flowmetry. While maintaining the stimulation voltage of 3.0V, frequency of 50Hz, pulse time of 1.0ms under the experimental conditions, the rapid increase of blood flow in the lumbar spinal cord. After 1 minute of electrical stimulation, the local blood flow in the lumbar spinal cord increased from 264.6 ± 17.1 PU to 317.5 ± 35.4 PU (P <0.001), and the blood flow increased after 15 minutes of continuous stimulation To an average peak of 366.0 ± 35.7 PU (P <0.001); blood flow increased from a baseline value of 76.4 ± 16.1 VU to an average peak of 111.1 ± 23.4 VU (P <0 .001). After stopping the electrical stimulation, the spinal cord blood flow gradually decreased and returned to baseline level. The longer the electrical nerve stimulation, the longer it takes for the spinal cord blood flow to return to baseline levels. Increased spinal cord blood flow and arterial blood pressure has nothing to do. Stimulation of the posterior tibial nerve, mainly containing exercise fibers, showed an increase in lumbar spinal flow that was significantly lower than the stimulation of mixed nerve sciatic and fibular nerves. The above results provide a theoretical basis for the clinical application of percutaneous electrical stimulation to relieve pain.