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目的探讨腹腔镜手术联合促性腺激素释放激素激动剂治疗子宫内膜异位症疗效。方法选取2011年5月-2016年4月114例子宫内膜异位症患者为研究对象,随机分成2组,对照组57例,采用腹腔镜常规治疗,研究组57例,在对照组基础上联合促性腺激素释放激素激动剂治疗,观察不同方法治疗后两组患者的疗效、生活质量等的差异。结果对照组治愈率36.84%、复发率29.82%、总有效率80.7%,观察组治愈率54.39%、复发率12.28%、总有效率91.23%,观察组治愈率、总有效率显著高于对照组,复发率显著低于对照组,两组比较差异有统计学意义(P<0.05);对照组治疗3个月、6个月后子宫内膜厚度、盆腔肿块大小分别为(5.45±1.23)mm、(3.45±1.11)cm,(3.31±1.12)mm、(2.78±0.94)cm,研究组相对应分别为(4.12±1.04)mm、(2.95±1.02)cm,(1.96±0.75)mm、(1.78±0.56)cm,研究组显著优于对照组,差异有统计学意义(P<0.05);对照组治疗后卵泡刺激素(FSH)为(6.24±2.31)U/L、黄体生成素(LH)为(6.11±3.21)U/L、雌二醇(E2)为(184.66±45.66)pmol/L,研究组FSH为(5.12±1.57)U/L、LH为(3.43±2.13)U/L、E2为(110.34±32.35)pmol/L,研究组显著优于对照组,差异均有统计学意义(均P<0.05)。结论腹腔镜手术联合促性腺激素释放激素激动剂治疗子宫内膜异位症临床效果显著,能改善患者激素水平。
Objective To investigate the efficacy of laparoscopic surgery combined with gonadotropin-releasing hormone agonist in the treatment of endometriosis. Methods A total of 114 patients with endometriosis from May 2011 to April 2016 were selected and randomly divided into two groups, 57 in the control group and 57 in the study group. On the basis of the control group Combined with gonadotropin-releasing hormone agonist treatment, observation of different methods of treatment of two groups of patients after treatment, quality of life differences. Results The cure rate of the control group was 36.84%, the recurrence rate was 29.82%, the total effective rate was 80.7%. The cure rate of the observation group was 54.39%, the recurrence rate was 12.28% and the total effective rate was 91.23%. The cure rate and total effective rate of the observation group were significantly higher than those of the control group , The recurrence rate was significantly lower than the control group, the difference between the two groups was statistically significant (P <0.05); control group 3 months, 6 months after the endometrial thickness, pelvic mass size was (5.45 ± 1.23) mm , (3.45 ± 1.11) cm, (3.31 ± 1.12) mm and (2.78 ± 0.94) cm in the study group were (4.12 ± 1.04) mm, (2.95 ± 1.02) cm and 1.78 ± 0.56) cm, the study group was significantly better than the control group, the difference was statistically significant (P <0.05); the control group after treatment follicle stimulating hormone (FSH) was (6.24 ± 2.31) U / L, ) Was (6.11 ± 3.21) U / L, E2 was 184.66 ± 45.66 pmol / L, FSH was 5.12 ± 1.57 U / L and LH was 3.43 ± 2.13 U / L , E2 (110.34 ± 32.35) pmol / L, the study group was significantly better than the control group, the differences were statistically significant (P <0.05). Conclusion Laparoscopic surgery combined with gonadotropin-releasing hormone agonist in the treatment of endometriosis has significant clinical effect and can improve hormone levels in patients.