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肿瘤细胞和宿主细胞或细胞外基质之间的相互粘连作用 ,是发生肿瘤转移的重要环节之一。RGD多肽聚乙二醇杂合物和寡糖的聚乙二醇缀合物都具有抗肿瘤转移的作用 ,RGD多肽 聚乙二醇 寡糖的杂合物也应当具有此功能的潜力。为了探索该类化合物的作用 ,设计且成功地合成聚乙二醇 RGD多肽 寡糖缀合物。
Tumor cells and the host cell or extracellular matrix adhesion between the role of the occurrence of tumor metastasis is an important part of. Both polyethylene glycol conjugates of RGD polypeptides polyethylene glycol and oligosaccharides have anti-metastatic effects and hybrids of RGD polypeptide polyethylene glycol oligosaccharides should also have the potential of this function. In order to explore the role of this class of compounds, polyethylene glycol RGD polypeptide oligosaccharide conjugates were designed and successfully synthesized.