论文部分内容阅读
目的 应用动态增强MRI两室药物代谢动力学模型评价TURP手术对前列腺癌、前列腺良性增生和正常前列腺周围带血液供应的影响。方法 对 78例经病理组织学证实的前列腺癌 ,其中TURP手术组 2 4例 ,对照组 5 4例 ,使用GE 1.5T超导磁共振成像仪 ,采用FSPGR序列针对前列腺 ( 4层或 5层 )进行动态增强扫描 ,层厚 7mm ,层间间隔 2mm ,连续扫描采样 35次。应用两室药物代谢动力学模型进行分析 ,分别计算出前列腺癌、前列腺良性增生和正常前列腺周围带的最大增强指数、对造影剂的吸收幅度、造影剂的交换率和造影剂分布指数。结果 TURP组和对照组之间年龄、病理学分级、PSA和肿瘤的分期、大小均未见明显差异 (Ρ >0 .0 5 )。在TURP组中肿瘤区最大增强指数、造影剂分布指数和正常前列腺周围带的最大增强指数明显高于对照组 ,之间存在显著统计学差异 (Ρ <0 .0 5 )。结论 MRI药物代谢动力学模型 ,特别是最大增强指数和造影剂分布指数能够更准确地反映TURP手术对前列腺癌组织和非肿瘤组织的血液供应变化
Objective To evaluate the effects of TURP on prostate cancer, benign prostatic hyperplasia (BPH) and blood supply around the normal prostate using dynamic contrast-enhanced MRI two-compartment pharmacokinetic model. Methods Totally 78 cases of prostate cancer confirmed by histopathology were examined. Twenty-four patients in the TURP group and 54 in the control group were treated with GE 1.5T superconducting magnetic resonance imager and the FSPGR sequence was used to detect prostate cancer (4th or 5th floor) Dynamic enhanced scanning, layer thickness 7mm, interlayer spacing 2mm, continuous scanning sampling 35 times. Two-compartment pharmacokinetic model was used to analyze the maximum enhancement index of prostate cancer, benign prostatic hyperplasia and normal prostatic band, absorption rate of contrast medium, exchange rate of contrast medium and contrast agent distribution index. Results There was no significant difference between the TURP group and the control group in age, pathological grade, stage and size of PSA and tumor (P> 0.05). In the TURP group, the maximum enhancement index, the contrast agent distribution index and the maximum enhancement index of the normal prostate band were significantly higher than those in the control group, with significant statistical difference (P <0.05). Conclusions MRI pharmacokinetic models, especially the maximal enhancement index and contrast agent distribution index, can more accurately reflect the changes of blood supply in prostate cancer tissue and non-tumor tissue by TURP surgery