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CD40是肿瘤坏死因子受体家族成员之一,其配体(CD40L,CD154)为肿瘤坏死因子家族成员之一。CD154-CD40交联不仅能够作为共刺激分子在机体的免疫反应中发挥重要作用,而且在调节肿瘤细胞的增殖与凋亡以及肿瘤的血管生成方面具有重要作用。本文即对CD40及CD154在泌尿系肿瘤中的表达及其意义进行综述。
CD40 is a member of the tumor necrosis factor receptor family and its ligands (CD40L, CD154) are members of the tumor necrosis factor family. CD154-CD40 cross-linking can not only play an important role as costimulatory molecules in the body’s immune response, but also play an important role in the regulation of tumor cell proliferation and apoptosis as well as tumor angiogenesis. This article reviews the expression of CD40 and CD154 in urological tumors and their significance.