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目的:比较基础抑制素B(basal inhibin B,bINHB)、基础卵泡刺激素(bFSH)、年龄、窦卵泡计数(AFC)对于体外受精中卵巢反应的预测价值。方法:选取首次施行体外受精/卵胞质内单精子注射-胚胎移植(IVF/ICSI-ET)患者796例,于促排卵开始前1个月,测定月经第3日血清bINHB、bFSH水平,B超测定当日卵巢内AFC,分别比较其与获卵数的相关性。结果:bINHB、AFC与获卵数呈正相关性,相关系数(r)分别为0.147和0.661;bFSH、年龄与获卵数呈负相关,r分别为-0.239和-0.355,均P<0.001。按|r|值行相关性排序,bINHB、bFSH、年龄、AFC与获卵数相关性递增。结论:bINHB、bFSH、年龄、AFC均可以预测卵巢反应性,AFC是预测卵巢反应最好的指标。
OBJECTIVE: To compare the predictive value of basal inhibin B (bINHB), basal follicle stimulating hormone (bFSH), age, and antral follicle count (AFC) in the ovarian response to in vitro fertilization. Methods: A total of 796 patients with in vitro fertilization / intracytoplasmic sperm injection-embryo transfer (IVF / ICSI-ET) were enrolled in this study. The levels of serum bINHB and bFSH, AFC in the ovary was measured on the same day, and their correlation with the number of oocytes retrieved respectively. Results: The positive correlations between bINHB and AFC were obtained, and the correlation coefficients (r) were 0.147 and 0.661 respectively. The bFSH, age and the number of oocytes retrieved were negatively correlated with r values of -0.239 and -0.355, all P <0.001. By | r | value row correlation sort, bINHB, bFSH, age, AFC and the number of oocytes retrieved ascendingly. Conclusion: bINHB, bFSH, age, AFC can predict ovarian response, AFC is the best indicator of ovarian response.