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目的观察喜炎平注射液辅助治疗急性有机磷农药中毒(AOPP)致呼吸肌麻痹(RMP)并发呼吸机相关肺炎(VAP)的临床效果。方法60例AOPP致RMP并发VAP患者随机分为试验组和对照组,两组患者均给予舒巴坦钠/头孢哌酮钠2.0g/12h静脉滴注,试验组在此基础上给予喜炎平注射液300mg静脉滴注,1次/d,疗程7d,在疗程结束时比较两者的疗效。结果试验组总有效率和细菌消除率(分别为88.89%和72.73%)高于对照组(分别为69.23%和52.38%)(P<0.05)。未见明显不良反应。结论喜炎平注射液是一种安全有效的治疗AOPP致RMP并发VAP的辅助药物。
Objective To observe the clinical effects of Xiyanping injection in the treatment of acute respiratory syndrome (PAP) associated pneumonia (VAP) caused by acute organophosphorus pesticide poisoning (AOPP). Methods Sixty AOPP-induced RMP complicated with VAP were randomly divided into test group and control group. Patients in both groups were given sulbactam sodium / cefoperazone sodium 2.0g / 12h intravenously. On the basis of this, the experimental group was given Xiyanping Injection 300mg Intravenous drip, 1 time / d, treatment 7d, at the end of the course of treatment compared the efficacy of both. Results The total effective rate and bacterial elimination rate in the experimental group (88.89% and 72.73%, respectively) were higher than those in the control group (69.23% and 52.38%, respectively) (P <0.05). No obvious adverse reactions. Conclusion Xiyanping injection is a safe and effective adjuvant for the treatment of AOPP-induced concurrent VAP.