肿瘤转移是肿瘤细胞与宿主细胞之间多种分子和基因相互作用的结果。近年来,通过分子克隆技术发现了一类参与调控肿瘤转移的基因。由于此类基因的失活、突变及表达异常,可导致肿瘤转移,表明具有抑制肿瘤细胞转移的作用,因此被称为转移抑制基因。自从第一个转移抑制基因NM23于198 Tumor metastasis is the result of a variety of molecular and gene interactions between tumor cells and host cells. In recent years, a class of genes involved in the regulation of tumor metastasis has been discovered through molecular cloning techniques. Because of such genes inactivation, mutation and abnormal expression, can lead to tumor metastasis, indicating that it has the role of inhibiting tumor cell metastasis, it is called metastasis suppressor gene. Since the first metastasis suppressor gene NM23 at 198