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目的检测二期梅毒患者血清IL-17,IL-23和维甲酸受体相关孤儿受体γt(ROR-γt)的水平,探讨Th17细胞在梅毒免疫致病机制中的可能作用。方法采用酶联免疫吸附法检测30例二期梅毒患者和20例正常人血清IL-17,IL-23和ROR-γt水平。结果 30例二期梅毒患者血清IL-17,IL-23和ROR-γt水平分别为(24.8±20.9)pg/mL,(32.1±8.3)pg/mL和(120.2±40.6)pg/mL,均较健康对照[(12.7±14.2)pg/mL,(21.0±8.7)pg/mL,(72.0±41.8)pg/mL]明显升高(P<0.05)。梅毒患者血清IL-17,IL-23和ROR-γt水平与RPR滴度间无线性相关(P>0.05)。结论梅毒患者血清IL-17,IL-23和ROR-γt水平的升高可能与梅毒的免疫致病机制有关。
Objective To detect the levels of serum IL-17, IL-23 and retinoic acid receptor-related orphan receptor γt (ROR-γt) in patients with secondary syphilis and to explore the possible role of Th17 cells in the pathogenesis of syphilis. Methods Serum levels of IL-17, IL-23 and ROR-γt were detected by enzyme-linked immunosorbent assay in 30 patients with secondary syphilis and 20 normal controls. Results The serum levels of IL-17, IL-23 and ROR-γt in 30 patients with secondary syphilis were (24.8 ± 20.9) pg / mL, (32.1 ± 8.3) pg / mL and (120.2 ± 40.6) pg / mL (P <0.05), which was significantly higher than that in healthy controls [(12.7 ± 14.2) pg / mL, (21.0 ± 8.7) pg / mL and (72.0 ± 41.8) pg / mL, respectively. Serum levels of IL-17, IL-23 and ROR-γt in syphilis patients were not correlated with RPR titres (P> 0.05). Conclusion The increase of serum IL-17, IL-23 and ROR-γt in syphilis patients may be related to the pathogenesis of syphilis.