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应用MTT法检测138例恶性实体瘤细胞体外对13种临床常用化疗药物的敏感性,探讨此方法作为肿瘤患者个体化用药预测的可行性。结果表明,本方法的可评价率为96.4％,体外药敏结果与临床化疗资料基本一致。结论:MTT法作为一种能为肿瘤患者化疗提供个体化实验室依据的准确、简便,快速方法值得临床推广应用。
The susceptibility of 138 malignant solid tumor cells to 13 clinically used chemotherapeutic drugs in vitro was detected by MTT assay, and the feasibility of this method as a predictor of individual drug use in tumor patients was explored. The results showed that the evaluable rate of this method was 96.4%, and the in vitro drug sensitivity results were basically consistent with clinical chemotherapy data. Conclusion: MTT assay is an accurate, simple and rapid method that can provide individualized laboratory evidence for chemotherapy for cancer patients. It is worthy of clinical application.