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选用可移植性小鼠结肠癌 C_(26)细胞,接种于 BALB/C 小鼠腹腔,模拟消化道肿瘤术后腹腔种植转移的发生过程。不同时期给予不同浓度药物治疗,腹腔灌注温度41.5℃,治疗40分钟。结果:接受治疗的各组小鼠中位生存期较单纯化疗、热疗及对照组延长(P<0.05)。灌注液相同时,接种后早期治疗(当天和3～4天)较晚期治疗(7～8天)生存期明显提高(P<0.05)。接种后同一时间接受治疗时,高浓度阿霉素(5μg/ml)灌注组较低浓度阿霉素(2.5μg/ml)组生存期延长,但无统计学意义。在灌注液、接种天数均相同时,加用吐温80组生存期显著提高(P<0.05)。实验证明,腹腔热灌注化疗对小鼠腹腔肿瘤(C_(26))治疗有效。
The transplantable mouse colon cancer C_(26) cells were selected and inoculated into the abdominal cavity of BALB/C mice to simulate the process of abdominal plantation metastasis after digestive tract tumor surgery. Different doses of drug treatment were given at different times and the intraperitoneal perfusion temperature was 41.5°C for 40 minutes. RESULTS: The median survival time of each group of treated mice was longer than that of chemotherapy alone, hyperthermia, and control group (P<0.05). Perfusion of the liquid phase at the same time, early treatment after inoculation (day and 3 to 4 days) than the late treatment (7 to 8 days) significantly improved the survival time (P <0.05). After being inoculated at the same time after inoculation, the survival time of doxorubicin (2.5 μg/ml) in the high-dose adriamycin (5 μg/ml) infusion group was prolonged, but it was not statistically significant. When the perfusion fluid and inoculation days were the same, the survival time of the Tween 80 group increased significantly (P<0.05). Experiments have shown that intraperitoneal hyperthermic perfusion chemotherapy is effective for the treatment of mouse abdominal cavity tumors (C_(26)).