论文部分内容阅读
目的:研究血浆氧化低密度脂蛋白(OxLDL)、高敏C反应蛋白(hsCRP)与动脉粥样硬化血栓形成性脑梗死之间的关系。方法:选取75例经头颅MRI确诊的动脉粥样硬化性脑梗死住院患者,腔隙性脑梗死、心源性栓塞性脑梗死及病因不明性卒中均不在收集范围;同时选取同期体检年龄、性别一致的健康人群32例作为对照组。采用ELISA试剂盒检测血浆OxLDL水平,高敏C反应蛋白采用免疫比浊法检测,其他脑梗死危险因素如年龄、性别、血脂等数据也一并收集。由同一名神经科专业医师参照美国国立卫生院卒中量表对病例组进行神经功能缺损评定即NIHSS评分。结果:病例组血脂、血浆OxLDL水平以及血清hsCRP含量均显著高于对照组(P<0.05),且血浆OxLDL水平、血清hsCRP水平与NIHSS(national institutes of healthy stroke scale)评分呈正相关(r=0.685,r=0.673;P<0.05),而血脂水平与NIHSS评分则无相关关系。结论:血浆OxLDL水平、血清hsCRP与动脉粥样硬化血栓形成性脑梗死严重程度有一定关系。
Objective: To investigate the relationship between plasma oxidized low density lipoprotein (OxLDL), high-sensitivity C-reactive protein (hsCRP) and atherothrombotic cerebral infarction. Methods: Seventy-five patients with atherosclerotic cerebral infarction diagnosed by head MRI were enrolled in this study. The lacunar infarction, cardioembolic infarction and unexplained stroke were all excluded. At the same time, the age, gender Thirty-two healthy healthy people served as the control group. The level of plasma OxLDL was measured by ELISA kit. The high-sensitivity C-reactive protein was detected by immunoturbidimetry. Other risk factors of cerebral infarction, such as age, sex and blood lipids, were also collected. The same neurosurgical physician referred to the National Institutes of Health Stroke Scale to assess the neurological deficit in the case group, the NIHSS score. Results: Serum levels of OxLDL and serum hsCRP were significantly higher in case group than in control group (P <0.05), and plasma oxLDL level and serum hsCRP level were positively correlated with NIHSS (r = 0.685 , r = 0.673; P <0.05), while there was no correlation between serum lipids and NIHSS score. Conclusion: The plasma level of OxLDL and serum hsCRP are related to the severity of atherothrombotic cerebral infarction.