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妊娠高血压约占孕妇5%,是胎儿及母体发病与死亡率的一个主要原因。但其病因及启动机制尚未明,人类胎盘产生多种激素与下丘脑释放激素及垂体激素相似。妊娠高血压妇女的促皮质素释放激素(CRH)较正常妊娠者高。本文旨在了解妊娠高血压妇女的血浆CRH、ACTH,β-内啡肽与氢化可的松等浓度及其相互关系。病人和方法妊娠高血压妇女14例,年龄20～39岁,孕期32～39周。正常妊娠妇女20名,年龄相同,孕期30～39周作对照。14例收缩压为145～200mmHg,舒张压为90～120mmHg。其中9例同时有蛋白尿,0.5～3g/L。12例在孕期经治疗或产后2周血压恢复正常。结果病例组平均CRH为4257±840ng/L,明显高于对照组的1083±227ng/L(P<0.001)。而ACTH病例组为65.0±6.0ng/L,只稍高于对照组的50.7±2.5ng/L(P<0.025)。β-内啡肽、氢化可的松及人胎盘催乳素则两组差异不大。对照组的
Gestational hypertension accounts for about 5% of pregnant women and is a major cause of fetal and maternal morbidity and mortality. However, its etiology and mechanism of activation is not yet clear, the human placenta produces a variety of hormones and hypothalamic hormone and pituitary hormone similar. Women with pregnancy-induced hypertension have a higher corticotropin-releasing hormone (CRH) than normal pregnant women. This article aims to understand the plasma CRH, ACTH, β-endorphin and hydrocortisone concentrations and their correlations in women with pregnancy-induced hypertension. Patients and Methods 14 cases of pregnancy-induced hypertension in women, aged 20 to 39 years, 32 to 39 weeks of pregnancy. 20 normal pregnant women, the same age, 30 to 39 weeks of pregnancy as a control. 14 cases of systolic blood pressure 145 ~ 200mmHg, diastolic blood pressure of 90 ~ 120mmHg. Of them, 9 cases also had proteinuria, 0.5 ~ 3g / L. Twelve patients were treated during pregnancy or returned to normal after 2 weeks of labor. Results The average CRH of cases was 4257 ± 840 ng / L, which was significantly higher than that of the control group (1083 ± 227 ng / L, P <0.001). The incidence of ACTH was 65.0 ± 6.0ng / L, which was only slightly higher than that of the control group (50.7 ± 2.5ng / L, P <0.025). β-endorphin, hydrocortisone, and human placental lactogenin did not differ significantly between the two groups. Control group