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本文观察了阿司匹林（Ｂ组）和维生素Ａ、Ｃ、Ｅ、叶酸（Ａ组）以及二者合用（Ｃ组）对孕鼠血清Ｚｎ、Ｆｅ、Ｍｎ、Ｃｕ及其胎鼠头部组织Ｚｎ、Ｆｅ、Ｍｎ、Ｃｕ、Ｃａ、Ｃｏ、Ｐｂ、Ｎｉ、Ｃｒ含量的影响．结果：Ｂ、Ｃ组孕鼠血清Ｆｅ、Ｍｎ、Ｃｕ含量较正常对照组（Ｎ组）高（Ｐ分别＜０．０５，＜０．００１，＜０．０１），而Ｚｎ有降低趋势．Ａ、Ｂ、Ｃ组胎鼠头部组织Ｚｎ、Ｆｅ、Ｃｕ含量均较Ｎ组降低（Ｐ＜０．０１），仅Ｍｎ含量较Ｎ组增高（Ｐ＜０．０１）；但Ｆｅ、Ｍｎ含量Ｂ、Ｃ组仍高于Ａ组（Ｐ＜０．０１）．而Ｐｂ、Ｎｉ含量Ａ、Ｂ组则明显高于Ｎ、Ｃ组（Ｐ＜０．０５．＜０．００１），Ａ组又低于Ｂ组（Ｐ＜０．０５，＜０．０１）．提示阿司匹林和维生素可促进孕鼠Ｆｅ、Ｍｎ、Ｃｕ的吸收，但抑制Ｚｎ吸收；孕鼠血清Ｆｅ、Ｃｕ含量与胎鼠头部组织Ｆｅ、Ｃｕ含量为负相关．Ｂ组胎鼠头部组织Ｐｂ、Ｎｉ含量高和Ｚｎ含量低可能是阿司匹林致畸原因之一，也是其毒性表现．
The effects of aspirin (group B) and vitamins A, C, E, folic acid (group A) and their combination on the serum Zn, Fe, Mn, Cu and fetal rat head tissue Zn, Fe , Mn, Cu, Ca, Co, Pb, Ni, Cr contents. Results: The contents of Fe, Mn and Cu in pregnant rats in groups B and C were significantly higher than those in normal control group (P <0.05, <0.001, <0.01, respectively), while Zn decreased. The contents of Zn, Fe and Cu in fetal head tissue in groups A, B and C were lower than those in group N (P <0.01), but only in Mn group (P <0.01), but Fe and Mn contents B, C group is still higher than A group (P <0.01). However, the contents of Pb and Ni in group A and B were significantly higher than those in group N and C (P <0.05 and <0.001), while those in group A and B were lower than those in group B (P <0.05 and <0.01). Tip aspirin and vitamins can promote the absorption of pregnant rats Fe, Mn, Cu, but inhibit the absorption of Zn; pregnancy serum Fe, Cu content and fetal head tissue Fe, Cu content is negatively correlated. The high content of Pb and Ni and the low content of Zn in the fetal rat head tissue of group B may be one of the causes of teratogenicity of aspirin and also their toxic manifestations.