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呼吸窘迫综合征(RDS),是未成熟儿死亡的主要原因,因此很多新生儿学者都作为主要的研究课题。1959年Avery和Mead对RDS的发病机理提出肺表面活性剂(Surfaetant)缺乏的观点以来,肺表面活性剂的研究已取得了很大的进展。最近,关于促进胎生肺脏的表面活性剂的合成预防RDS发病,测定羊水中的表面活性剂诊断出生前RDS以及经呼吸道投予合成的表面活性剂治疗RDS等,正在研究和发展。尤其是把肺表面活性剂作为指标的有关胎儿肺的成熟的研究,发现了成熟促进因子和迟延因子及其相互关系,已超越新生儿学的范畴,成为发育生物学的中心课题。
Respiratory distress syndrome (RDS), which is the leading cause of death in immature infants, has led many neonatologists to be the main research topic. Great progress has been made in the study of pulmonary surfactant since Avery and Mead proposed the lack of surfactant (Surfaetant) in the pathogenesis of RDS in 1959. Recently, studies on the synthesis of surfactants for promoting the growth of the lungs of the lung to prevent the onset of RDS, determination of surfactants in amniotic fluid for the diagnosis of prenatal RDS, and surfactant for the synthesis of RDS through the respiratory tract are under study and development. In particular, pulmonary surfactant as an indicator of fetal lung maturation studies found that maturation promoting factor and delay factor and their relationship, beyond the scope of neonatology, has become the center of developmental biology.