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棉酚是我国首创的一种男性节育药,其抗生育作用已在临床及动物实验中得到证实。但有少数人服药后出现低血钾肌无力症。各实验室从不同方面观察了棉酚与低血钾的关系,并阐明了各自的观点。我们曾分别观察了对猴、大鼠、豚鼠喂服不同剂量棉酚的急性实验,而本文报道长期喂服棉酚对大鼠肾Aa-K-ATP酶影响的电镜观察。
Gossypol is a male male birth control medicine first introduced in China. Its anti-fertility effect has been confirmed in clinical and animal experiments. However, a few people have hypokalemia muscle weakness after taking the drug. The laboratories observed the relationship between gossypol and hypokalemia from different aspects and clarified their respective viewpoints. We have observed the acute experiments of different doses of gossypol in monkeys, rats and guinea pigs, and this article reports the effect of long-term administration of gossypol on rat kidney Aa-K-ATPase by electron microscopy.