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1991年Sem enza等[1]发现1种蛋白特异性地结合于促红细胞生长(erythropoietin,EPO)基因增强子的寡核苷酸序列;1992年,他们分离克隆出二聚体,由乏氧诱导的亚基被命名为乏氧诱导因子-1(hypoxia-induc ib le factor-1,H IF-1)[2]。它连接在红细胞生成素基因低氧反应元件(hypoxia r
In 1991, Sem enza et al [1] found an oligonucleotide sequence that specifically binds to the erythropoietin (EPO) gene enhancer; in 1992, they isolated and cloned dimers that were induced by hypoxia Of subunits were named hypoxia-inducible factor-1 (HIF-1) [2]. It is linked to an erythropoietin hypoxia response element (hypoxia r