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美登醇(1)是美登素类化合物(Maytansinoids)(2)的共同母体,后者为前者的酯类,普遍显示抗癌作用。美登醇已由日本学者经发酵途径大量获得并转变成美登素类化合物。美登醇的复杂结构是对有机合成化学家的挑战,Corey和Meyers二研究集团首先完成了全
Maytansinol (1) is the common parent of Maytansinoids (2), the latter being esters of the former, generally showing anti-cancer effects. Maythanol has been largely obtained by Japanese scholars via fermentation and converted into maytansinoid compounds. The complex structure of maytansinol is a challenge to organic synthesis chemists. Corey and Meyers II Research Group completed the first