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目的了解串珠镰刀菌的致病性,观察不同浓度和不同免疫状态下串珠镰刀菌小鼠局部皮肤感染情况。方法对免疫正常组和免疫抑制组小鼠皮下接种串珠镰刀菌,接种后每日观察接种部位皮损情况,记录皮损类型、特点及变化情况,观察4周。取小鼠的皮损做病理检查和真菌培养。结果免疫正常组和免疫抑制组小鼠均见局限性感染,对照组小鼠未见感染;感染程度:相同免疫状态下,高浓度组>低浓度组;相同接种菌量下,免疫抑制组>免疫正常组。结论串珠镰刀菌有致病性,小鼠免疫状况和致病菌接种量是串珠镰刀菌致病的关键因素。
Objective To understand the pathogenicity of Fusarium moniliforme and to observe the local skin infections of Fusarium moniliforme in different concentrations and different immune states. Methods Normal mice and immunosuppressed mice were inoculated subcutaneously with Fusarium moniliforme. After inoculation, the skin lesions at the inoculation site were observed daily. The types, characteristics and changes of lesions were recorded and observed for 4 weeks. Take the mouse skin lesions for pathological examination and fungal culture. Results The mice in the immunized group and the immunosuppressed group were all found to have a localized infection. The mice in the control group showed no infection. The levels of infection were the same in the immunized group, the high concentration group and the low concentration group. The immunosuppressive group> Immune normal group. Conclusion Fusarium moniliforme has pathogenicity, immune status of mice and pathogen inoculation is the key factor causing Fusarium moniliforme pathogenicity.