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本文报道了用反相高效液相色谱分离与鉴定家兔血浆中天麻素及其代谢产物对羟基苯甲醇(甙元)的方法,并测定家兔静注天麻素后原形药与其甙元的血药浓度。选用YacT—CH色谱柱,流动相为甲醇:水(2.5:97.5),紫外检测波长221nm。以间苯三酚为内标物。样品中的天麻素,甙元检测极
In this paper, a method for the separation and identification of gastrodin and its metabolite p-hydroxybenzyl alcohol in rabbit plasma by reversed-phase high-performance liquid chromatography (HPLC) was reported. The rabbit plasma and its aglycon blood were measured after intravenous injection of gastrodin. Drug concentration. The YacT-CH column was used. The mobile phase was methanol:water (2.5:97.5) and the UV detection wavelength was 221 nm. With phloroglucinol as the internal standard. Gastrodin in the sample