Background Percutaneous coronary intervention(PCI) is used as a treatment for acute myocardial infarction(AMI),and one of its major complications is the angiographic no-reflow phenomenon(NR).Although intra-aortic balloon pumping(IABP) is sometimes used in such patients to increase the diastolic coronary blood flow,there is little available information regarding the effects of IABP on the angiographic no-reflow phenomenon.Method Twenty-two AMI patient with NR were performed primary PCI between January 2006 and December 2009,of which 12 patients were selected for IABP therapy and the left 10 were selected as the control group by group procedure of odd and even days;We observed the vasoactive substance in both groups on the days of 1,2,3,5,7,10 after the different interventions,which include plasma renin activity(PRA),angiotensin II(ANGⅡ),aldosterone(ALD),adrenaline(E),and noradrenalin(NE);In addition,cardiac structure and cardiac ventricle systolic function including left atrium medial diameter(LAMD),left ventricular medial diameter(LVMD),left ventricular ejection fraction(LVEF) were evaluated after 10 days,3 months and 6 months;Finally,statistics was taken to analysis.Results According to the time concentration curve,vasoactive substance of the IABP group decreased faster than that of the control group,and this difference had statistical significance(P < 0.01);In terms of LAMD,LVMD,and LVEF,echocardiography difference of the IABP and the control group in 10 days,3 months,and 6 months also showed statistical significance(P < 0.05).Conclusions IABP can significantly reduce the release of vasoactive substances of NR in patients of primary PCI for AMI;LAMD,LVMD and LVEF in 10 days,3 months,and 6 months can be improved using this method,which is conducive to recovery of heart function. Background Percutaneous coronary intervention (PCI) is used as a treatment for acute myocardial infarction (AMI), and one of its major complications is the angiographic no-reflow phenomenon (NR) .Although intra-aortic balloon pumping (IABP) is sometimes used in such patients to increase the diastolic coronary blood flow, there is little available information regarding the effects of IABP on the angiographic no-reflow phenomenon. Method Twenty-two AMI patient with NR were performed primary PCI between January 2006 and December 2009, of which 12 patients were selected for IABP therapy and the left 10 were selected as the control group by group procedure of odd and even days; We observed the vasoactive substance in both groups on the days of 1,2,3,5,7,10 after the different interventions, which include plasma renin activity (PRA), angiotensin II (ANG II), aldosterone (ALD), adrenaline (E), and noradrenalin diameter, left ventricular medial diameter (LVMD), left ventricular ejection fraction (LVEF) were taken after 10 days, 3 months and 6 months; Finally, statistics was taken to analysis. Results according to the time concentration curve, vasoactive substance of the IABP group decreased faster than that of the control group, and this difference had statistical significance (P <0.01); In terms of LAMD, LVMD, and LVEF, echocardiography difference of the IABP and the control group in 10 days, 3 months , and 6 months also showed statistically significant (P <0.05) .Conclusions IABP can significantly reduce the release of vasoactive substances of NR in patients of primary PCI for AMI; LAMD, LVMD and LVEF in 10 days, 3 months, and 6 months can be improved using this method, which is conducive to recovery of heart function.