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目的 ,总结强直性脊柱炎 (AS)的临床特点 ,提高诊治水平。方法 :回顾性分析 1992～ 1999年间诊治的 38例AS病人的临床资料。结果 38例 AS中 ,男 34例 ,女 4例。平均发病年龄 2 8岁 ;首发症状为慢性腰痛者 2 9例占 76 .32 % ;关节外表现仅见虹膜炎 4例占 10 .5 2 % ;骨盆正位片全部有骶髂关节炎占 10 0 % ;HL A- B2 7阳性 3.5例占 92 .10 % ;17例误诊占 44 .73% ;治疗药物主要有非甾体类抗炎药 (NSAIDs)、柳氮磺胺吡呤 (SSZ)、甲氨蝶呤 (MTX)、糖皮质激素等。结论 AS多见于青年男性 ,其首发症状多为慢性腰痛 ,临床易误诊 ,骨盆正位片骶髂关节炎及 HL A -B2 7阳性有助于早期诊断和治疗。
Objective To summarize the clinical features of ankylosing spondylitis (AS) and improve the diagnosis and treatment. Methods: The clinical data of 38 AS patients diagnosed and treated between 1992 and 1999 were retrospectively analyzed. Results 38 cases of AS, 34 males and 4 females. The average age of onset was 28 years. The first symptom was chronic lower back pain in 29 cases, accounting for 76.32%. The only manifestations of extra-articular iridis were in 10.52% cases. The pelvic anteroposterior sacroiliitis accounted for 10% %; HL-B2 7 positive accounted for 92.10% of cases; 17 cases misdiagnosed 44.73%; treatment of non-steroidal anti-inflammatory drugs (NSAIDs), sulfasalazine Methotrexate (MTX), glucocorticoids and the like. Conclusions AS is more common in young males. The first symptom is mostly chronic lumbago. Clinical misdiagnosis, pelvic anterior sacral and iliac arthritis, and HL A-B2 7 positivity are helpful for early diagnosis and treatment.