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本文所介绍的导管术系将硅胶管经颈外静脉和幽门静脉分别插入麻醉大白鼠的上腔静脉口及肝门静脉与幽门静脉交界处。导管内充满肝素盐水,经皮下由后背穿出固定。术后动物长期存活,可重复给药、取血样。适用于药代动力学、肝脏首过效应、肠道、肝脏生理学、生物化学等方面的研究。该肝门静脉导管术与国外现有导管术相比,具有动物小、手术创伤小、动物长期带管存活和可以用自身对照方法进行交叉试验等优点。本文用该法研究了非那根的药代动力学。
The catheterization technique introduced in this paper inserted the silicone tube into the superior vena cava mouth and the junction between the hepatic portal vein and the pyloric vein through the external jugular vein and the pylorus vein respectively. Catheter filled with heparin saline, pierced by the back of the skin fixed. After long-term survival of animals can be repeated administration, take blood samples. For pharmacokinetics, the first pass the liver effect, intestinal, liver physiology, biochemistry and other aspects of the study. Compared with the current catheterization abroad, the hepatic portal venous catheterization has the advantages of small animals, small trauma, long-term survival of the animals and cross-testing with their own control methods. In this paper, the pharmacokinetics of phenanthrene was studied.